ADHD is the most common neuropsychiatric disorder of childhood, and is characterised by high levels of activity, impulsivity, and inattention. These symptoms tend to lead to poor academic outcomes for affected individuals, as well as impacting interpersonal relationships. ADHD has a large genetic component, but despite a large effort to detect genetic associations with ADHD, little has been done to functionally characterise these associated genes and determine their relevance in ADHD progression.
We have been investigating the genetic background of ADHD, taking ADHD-associated genes and examining their functional importance in the development of the disorder. Using zebrafish models we are able to examine changes in activity, as well as alterations in brain structure, neuronal branching, and neurotransmitter receptor regulation.
Attention Deficit Hyperactivity Disorder